The role of the noncanonical Wnt signaling pathway [99], as well as the role of TGF-β1 in the stimulation of aortic valvular interstitial cells, leading to morphological changes consistent with myofibroblastic transformation, BMP-2 signaling, and calcification, seem to be of particular interest in relation to AV stenosis and aneurysm [100,101,102]. The gene discussed is TGFB1; the disease is aneurysm.