Similar observations were made by Suzuki et al. who found in a Japanese population that the relative risk (RR) of non-cardia gastric cancer in H. pylori seropositives with positive low CagA antibody titres was greater (RR = 3.9; p < 0.001) than that of subjects with high CagA antibody titres (RR = 2.0; p = 0.002) [70]. This evidence concerns the gene S100A8 and gastric cancer.