It is also reported that macrophages isolated from the mouse and human tumors can directly suppress T cell responses in vitro (Ruffell and Coussens, 2015), and that depletion of TAM enhances CD8+ T cell-mediated anti-tumor immunity in the mammary tumors in mice under treatment with chemotherapy (DeNardo et al., 2011). The gene discussed is CD8A; the disease is neoplasm.