MMP2 and myocardial infarction: In the present experiment, we have investigated the association between decreased myocardial blood flow and the acute oxidative stress marker MMP-2, and the effect of increased MMP-2 on the homing, biodistribution, and paracrine effect of the cardiac delivered MSCs, in the pig closed-chest, reperfused myocardial infarction (MI) model in a side-by-side comparison of IC and intramyocardial delivery modes.