CDKN2A and neoplasm: In adjusted analysis using a multivariable Cox proportional hazards model, AJCC pathologic tumor stage (HR: 1.86; 95% CI: 1.06–3.26), receipt of chemotherapy (HR: 1.87; 95% CI: 1.12–3.12), and CDKN2A copy number loss (HR: 1.42; 95% CI: 1.01–2.00) remained significant (Table 3).