KLF5, a member of the KLF family known as Gut-Enriched Kruppel-Like Factor (GKLF) has been characterized as a transcription factor which is expressed in high amounts in the cells of the intestinal epithelium.13 Previous studies reported an intense association between KLF5 overexpression and some metabolic disorders such as cardiovascular disease and diabetes.14 It has been proved that the translation of KLF5 is controlled by microRNAs (miRNAs).15 The gene discussed is KLF5; the disease is metabolic disease.