After analyzing the serum HMGB1 and TLR4 expressions, the PD patients with good therapeutic outcomes (effective group) were found to have serum HMGB1 and TLR4 expressions of 4.25 ± 0.65 and 2.31 ± 0.87, respectively, which were significantly lower than those of the PD patients with poor therapeutic outcomes (refractory group), who had serum HMGB1 and TLR4 expressions of 6.43 ± 1.14 and 3.10 ± 0.93, respectively (p < .05, Table 4). Here, HMGB1 is linked to Parkinson disease.