The HMBG1 level in the peripheral blood was significantly higher in the PD group (5.96 ± 2.1) than in the control group (1.3 ± 0.18, p < .05); similarly, the TLR4 level in the peripheral blood was significantly higher in the PD group (2.56 ± 0.78) than in the control group (0.87 ± 0.12, p < .05; Table 2). This evidence concerns the gene TLR4 and Parkinson disease.