Considering the neuroprotective effects of bile acids, a set of neurodegenerative diseases have been reported, including PD, Alzheimer's disease (AD), and Huntington's disease (HD), but the available data for HSD3B7 are limited (Ackerman & Gerhard, 2016; Ramalho et al., 2013; Rodrigues et al., 2000). Here, HSD3B7 is linked to early-onset autosomal dominant Alzheimer disease.