In a previous study, Abdelsayed et al. (24) determined that intense PTHrP expression was observed only in conventional ameloblastomas, whereas unicystic ameloblastomas showed weaker levels of expression, hypothesizing that PTHrP expression is related to greater bone destruction in conventional ameloblastoma, and to the less aggressive behavior observed in unicystic tumors. The gene discussed is PTHLH; the disease is ameloblastoma.