However, the fasting insulin concentration at the end of the study in the DM group (3.50 ± 1.14 nmol/l) was significantly greater when compared to those in the DM + DSS (2.22 ± 1.02 nmol/l, p = 0.035) and non-DM control (0.37 ± 0.16 nmol/l, p = 0.007) groups, suggesting that DSS treatment might improve insulin resistance in the db/db mice. Here, INS is linked to diabetes mellitus.