IGHE and Increased total eosinophil count: Preplanned analyses of the PrimoTinA-asthma (severe) and MezzoTinA-asthma (moderate) found that ∼20%/∼15% of severe/moderate patients had elevated IgE (≥430 μg/L) and that ∼10%/∼5% of severe/moderate patients had blood eosinophilia (≥0.6 × 109), respectively; analyses were then performed in subgroups of patients with TH2- and non-TH2-asthma, the former defined by the presence of both elevated IgE and blood eosinophilia [28, 29].