MMP2 and hypertensive disorder: In addition, Palei et al. [28] found −1306C/T and −735C/T MMP2 SNPs to be associated with elevated MMP2 levels in the plasma of preeclamptic Brazilian women and mothers whose pregnancies were accompanied by hypertension; however, they did not find any significant differences in the genotype or allele frequency distributions for the two SNPs when hypertensive or preeclamptic patients were compared with healthy cases [28].