Additionally, we observed that simultaneous maternal and fetal 1G/1G homozygosity increases the risk of preeclampsia development 2.39-fold (OR = 2.39, 95% CI 1.01–5.65), whereas the set of maternal 5A/5A and fetal 5A/6A MMP3 genotypes elevates the risk of occurrence of the studied disease 4.57 times (OR = 4.57, 95% CI 1.85–11.26). This evidence concerns the gene MMP3 and preeclampsia.