CD5 and B-cell chronic lymphocytic leukemia: However, the earliest transcriptome analyses of CLL and normal B-cell subsets suggested that mutated and unmutated CLL B-cells display a homogeneous GEP that is largely independent of their VH mutation status and is more strongly related to MBCs than of cells derived from naive B-cells, cord blood CD5+ B-cells, or GC B-cells (centroblasts/centrocytes) (172).