Although polyreactivity has been previously described in about 80% of unmutated CLL cases and only 15% of mutated CLL (211), Herve et al., in an in vitro study, reverted mutated CLL B-cell Abs to their original germline sequences (non-mutated) and showed that they encode poly- and autoreactivity Abs (211). The gene discussed is DDX41; the disease is B-cell chronic lymphocytic leukemia.