However, the existence of BCR stereotypy in the normal repertoire was evidenced by the identification of stereotypic IGHV1-69/IGHJ6 rearrangements (that constitute 13% of all CLL and 25–30% of unmutated-CLL) in circulating naive B-cells of healthy elderly individuals (206). Here, BCR is linked to B-cell chronic lymphocytic leukemia.