Moreover, although polymorphisms of SLAM family members are associated with autoimmunity in lupus-prone mouse strains and humans (37), and with alterations in NKT cell numbers in NOD (non-obese diabetic) mice (86), to date, there have been no reports of immunodeficiency or EBV susceptibility associated with mutations of other SLAM family members in humans (36). The gene discussed is SLAMF1; the disease is systemic lupus erythematosus.