Some have gone so far as to say cancer cells “hijack [host immune] tolerance [and suppression] (215).” It is for these reasons that many researchers are attempting to use approved cancer immunomodulation agents for sepsis therapy (e.g., anti-PD-1/PD-L1 Ab, anti-CTLA-4 Ab) (185) (Figure 4). The gene discussed is CD274; the disease is Sepsis.