Sepsis is associated with alterations in immune effector cells including defects in antigen presentation, quantitative and qualitative alternation in neutrophils, defective NK cell-mediated immunity, defective T and B cell-mediated immunity, relative increases in regulatory T cells (Tregs), an increased expression of PD-1/PD-L1, decreased immunoglobulin levels, hypercytokinemia, and complement consumption. This evidence concerns the gene CD274 and Sepsis.