IFNA1 and Epileptic encephalopathy: Abnormal upregulation of type 1 IFN signaling and gene expression stimulated by IFN have been tied to “interferonopathies,” a common moniker for a group of CNS diseases that includes AGS (284), a pediatric-onset epileptic encephalopathy characterized by increased CSF IFN-α, CCL2, and CXCL10 (104).