Apart from the cases above, another one has been described with fulminant encephalomyelitis, but with detection of both MOG-IgG (early in the disease course) and AQP4-IgG (later on); in this case, the histopathological aspect of lesions represented an overlap of features compatible with pattern II MS and features usually seen in AQP4-IgG-seropositive NMOSD (43). The gene discussed is AQP4; the disease is encephalomyelitis.