Furthermore, several studies have shown that vascular remodeling of resistance arteries after reduced blood flow, hypertension, or exposure to vasoconstrictors depends on tissue-TG2 activity to stabilize arterial wall and normalize shear stress (Bakker et al., 2005, 2006; Eftekhari et al., 2007; Pistea et al., 2008). The gene discussed is TGM2; the disease is hypertensive disorder.