Activating K-Ras mutations, mainly in codon 12, are the first genetic changes detected during the progression of pancreatic cancer and are present in 75–90% of all pancreatic adenocarcinomas (Shibata et al., 1990; Dergham et al., 1997; Wang et al., 2002). The gene discussed is KRAS; the disease is pancreatic neoplasm.