In accordance with these previous findings, a recent study on non-small cell lung cancer also showed that the interaction between the cytoplasmic domain of MUC1 with the SH2 domain of PI3K p85 subunit is critical for the activation of the PI3K-Akt-mTOR pathway (Kato et al., 2007). The gene discussed is PIK3CA; the disease is non-small cell lung carcinoma.