The present study verifies the pharmacological effects of SCE (108 mg/kg/day), especially its effects on promoting the translocation of GLUT4 and lowing BG by promoting GLUT4 translocation through the activation of the PI3K–Akt–AS160 signalling pathway in rats with DM induced by high-energy diet and low-dose STZ. The gene discussed is SLC2A4; the disease is diabetes mellitus.