AR and posterior cortical atrophy: PI3K/Akt/mTOR complex-1 (mTORC1) and the androgen receptor are two major drivers of PCa, and the PI3K/Akt/mTOR signaling pathway plays a key role in anticancer drug-mediated regulation of autophagy in human PCa cells (Wang et al., 2016; Kim et al., 2017; Lin et al., 2017).