NQO1 and Alzheimer disease: In this regard, it is noteworthy that Xn, acting as a weak electrophile Michael acceptor, is thought to exert chemopreventive effects via induction of detoxification enzymes such as NADPH quinone oxidoreductase 1 (NQO1) (Dietz and Bolton, 2011), which has also been associated with AD (Chhetri et al., 2017).