In our study, analysis of SYT1 levels in the whole hippocampus of rats selected by the MWM test alone, as in the study of Nicolle et al. (1999), failed to highlight a difference (Figure 2), whereas analysis of SYT1 levels in the whole hippocampus of rats categorized with both the MWM and the STPA tests demonstrated a significant increase of SYT1 level in rats with cognitive impairment (117.2% ± 5.64% vs. Non-Impaired rats; p = 0.029, Mann Whitney test; Figure 2). Here, SYT1 is linked to Cognitive impairment.