TARDBP and amyotrophic lateral sclerosis: The dysregulation of let-7b was, until now, determined in connection with ALS in TDP-43 knockdown in culture cells, where the authors showed that the removal of TDP-43 from the cell nucleus caused specific downregulation of let-7b that could further influence the expression of other potential transcripts involved in neurodegeneration and synapse formation (Buratti et al., 2010).