DNM2 and centronuclear myopathy: Interestingly, the DNM2 gene, which we revealed as down-regulated in our sALS patient samples, was also previously found to be mutated in Charcot-Marie-Tooth neuropathy type CMT2M, a motor and sensory neuropathy primarily affecting peripheral nerves (Züchner et al., 2005) and in centronuclear myopathy (CNM), presenting with primary damage in skeletal muscles (Bitoun et al., 2005).