Thus, dysfunctional or dysregulated DNM2 connects hereditary spastic paraplegia, Charcot-Marie-Tooth neuropathy (CMT2M), and centronuclear myopathy (CNM), and according to our new findings, it also connects at least a subset of sporadic ALS cases. Here, DNM2 is linked to Charcot-Marie-Tooth disease, axonal, type 2FF.