Since the connection between AATK and frontotemporal dementia and DNM2 and Charcot-Marie-Tooth (type CMT2M), centronuclear myopathy (CNM), and hereditary spastic paraplegia was discovered in recent studies, these two genes together with the results in this study genetically connect, at least in part, five diseases, including FTD, HSP, CMT2M, CNM, and ALS, and thus opens future research toward a better understanding of the cell biological processes involved in these partly overlapping complex clinical syndromes. The gene discussed is AATK; the disease is hereditary spastic paraplegia.