PSEN1 and Alzheimer disease: In this study, we identified CHRD as a candidate gene with a genome-wide significant p-value (5 × 10−07) reported by three tests, and another six genes that had a suggestive genome-wide p < 5 × 10−04 in at least five, and up to nine, of the different test performed: CLCN2, CPAMD8, HDLBP, MAS1L, NLRP9, and PTK2B. Additionally, these genes seem to have direct and indirect interactions (genetic interaction, co-localization or shared function) with known AD genes (APP, PSEN1, PSEN2, APOE, TREM2, PLD3, and ADAM10).