PSEN2 and Alzheimer disease: We used the GeneMANIA (http://pages.genemania.org/) algorithm on the seven candidate genes (CHRD, MAS1L, PTK2B, CPAMD8, NLRP9, CLCN2, and HDLBP) and known AD-related genes (APP, PSEN1, PSEN2, APOE, TREM2, PLD3, and ADAM10) which are involved in some pathways important in AD (APP-metabolism and immune response).