Firstly, the focus of our review is on autonomic dysfunction associated with CLZ while it is believed CLZ-induced myocarditis arises from type 1 hypersensitivity mediated by immunoglobulin E (IgE) (Kilian et al., 1999) or of viral origin (Merrill et al., 2006). The gene discussed is IGHE; the disease is Abnormal autonomic nervous system physiology.