Dexamethasone reduced IL-6, IL-8, and PGE2 induced by IL-1β in osteoarthritic and RA fibroblasts [66]; reduced IL-6 and only minor IL-8 in HUVEC in response to TNFα [67]; and decreased constitutive MCP-1, but not induced MCP-1 by TNFα [68]. This evidence concerns the gene TNF and rheumatoid arthritis.