IL6 and melanoma: For instance,non-tumourigenic melanoma cells exposed to IL6 or chemokine ligand-2 (CCL2)develop tumourigenic potential in vivo in a STAT3-dependent manner.54 In vitro, co-culture experiments showed that SASP induced theexpression of critical reprogramming factors NANOG, SOX2, and OCT4.54 Indeed, it has further been shown that increased IL6 expression,through induction of senescence either genetically or from tissue damage, cancreate a tissue context that increases reprogramming efficiency in vivo.