TP53 and hepatocellular carcinoma: For example,senescent cells promote their own clearance through the secretion of CCL2, whichattracts and activates NK-T cells.73,74 Using a mouse model of liver carcinoma, p53-deficient RAS-driventumours induced to senesce through re-establishment of p53 function exhibitedinnate immune cells migrating into the vicinity of the senescent tumour area,leading to complete tumour regression.24 Such senescence-induced activation of the local immune system hasalso been shown to activate the clearance of pre-malignant hepatocytes.75