One effect of NF1 haploinsuffiency used as first read out is the relative mechanosensoric blindness to micro-nano-structures measured as reduced capability to orientate themselves on polydimethysiloxane (PDMS) gels structured with parallel elevations of 200 nm height and a width of 2 μm, as described for fibroblasts derived from NF1 patients9. The gene discussed is NF1; the disease is Blindness.