We also assessed a role of activated HER2 in Kras-driven pancreatic neoplasms, by using mice harboring activated HER2 and/or Kras mutation in pancreas11, and found that a cooperative role between activated HER2 and oncogenic Kras accelerated the development of pancreatic intraepithelial neoplasms. This evidence concerns the gene KRAS and pancreatic neoplasm.