Interestingly, the classification of adenomas by size into 3 groups, less than 10 mm, between 10 and 20 mm, and greater than 20 mm, as previously reported4 revealed that patients with larger adenomas had numerically higher levels of IGF-1 and basal or nadir GH after OGTT, although these changes were not statistically significant within groups (Table 1). The gene discussed is IGF1; the disease is adenoma.