Reduced PCAF, ADA3, and PACS1 expression may have implications for gastric cancer tumorigenesis given our findings that PCAF and ADA3 expression are reduced on stage I disease but not in adjacent tissues affected by pre-malignant change (CG or IM), and that PACS1/PACS2 play an important role as effectors of apoptosis through the intrinsic pathway15,17. The gene discussed is PACS1; the disease is gastric cancer.