Interestingly, the level of p-p38 (T180/Y182) was markedly reduced in the cKO kidneys under both physiological conditions and AKI, whereas the levels of p-ERK (T202/Y204) and p-JNK (T183/Y185) were similar in the control and cKO kidneys, under either physiological conditions or AKI (Figs. 5a, b). The gene discussed is MAPK8; the disease is acute kidney injury.