SQLE and cancer: Using siRNA targeting SQLE specific for squalene epoxidase in cholesterol synthesis, FNTB for FT, PGGT1B for geranylgeranylation type I, and RABGGTB for geranylgeranylation type II, we found that the M1 virus protein expression levels were enhanced accordingly after FNTB knockdown in both the HCT-116 and SW1990 cancer cell lines but not in the normal cell line L02 (Fig. 2g), suggesting that the protein farnesylation branch is the potential branch mediating antiviral function.