However, decreased AEG-1 expression was not observed in the hippocampus of patients with AD compared to age-matched controls, even though there was a significant loss of neuronal nuclei (NeuN, a marker of neurons) in that region in the patients compared to controls (Fig. 1f, g; #p = 0.001 vs. CON). The gene discussed is MTDH; the disease is Alzheimer disease.