The aberrant activation of apoptotic signaling pathways in the adult brain is a well-known neurotoxic event that is associated with neuronal loss, such as that observed in neurodegenerative diseases, including Parkinson’s disease (PD) and Alzheimer’s disease (AD)6–8, and the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway has been shown to elicit neuroprotective effects on the survival and growth of neurons in the nigrostriatal dopaminergic (DA) system9–11. This evidence concerns the gene AKT1 and Alzheimer disease.