We recently demonstrated that the Rheb(S16H) delivery-induced activation of mTORC1 in DA neurons protects and reconstructs the damaged nigrostriatal DA projections in a mouse model of PD, which suggested that the activation of the Akt/mTORC1 signaling pathway might be a promising therapeutic strategy for the functional recovery of DA neurons9,10. Here, RHEB is linked to Parkinson disease.