AKT1 and amyotrophic lateral sclerosis: The downregulation of neuronal AEG-1 has recently been shown to reduce the viability of motor neurons in a mouse model of amyotrophic lateral sclerosis (ALS) by activating apoptotic signaling pathways via inhibition of the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/Akt) signaling pathway5.