Western blot analyses revealed significant decreases in the levels of AEG-1 and tyrosine hydroxylase (TH, a marker of DA neurons) in the SN of the patients with PD compared to age-matched controls (Fig. 1c; #p = 0.033 and *p = 0.022 for AEG-1 and TH, respectively, vs. CON). Here, MTDH is linked to Parkinson disease.