Moreover, inherit dynamic expression [38,39], highly heterogeneous [12,40], or down-regulation of the anchor protein EpCAM which associates with epithelial-to-mesenchymal transition (EMT) and cancer progression as well as metastasis [41,42], will result in failure to isolate those “uncapturable” EpCAM negative CTCs by means of the anti-EpCAM strategy or its derived techniques [43,44]. Here, EPCAM is linked to cancer.