CDK4 and cancer: In addition, CDK4/cyclin D inhibition may be additionally beneficial for the treatment of human epidermal growth factor receptor 2 (HER2) and RAS‐driven breast cancers (Yu et al, 2001; Goel et al, 2016) and potentially many other cancers because cyclin D1 displays most frequent somatic copy number aberrations of all cancer genes (Leiserson et al, 2015).