We observed that the proportion of LGR5-positive ISCs was increased in the intestinal crypts in SBS rats, and additionally increased when SBS rats were orally administered BSDL. Our study strongly supported the concept that the oral administration of BSDL could have potentially sustainable and long-term effects on the intestinal adaptive growth in the setting of SBS. The gene discussed is LGR5; the disease is macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.