HIV-1 IMCs carrying panels of heterologous HIV-1 env sequences (Env-IMCs) in an isogenic backbone and expressing the Renilla luciferase (LucR) reporter, which allows highly sensitive, quantitative readout of productive infection (34), have been widely used to evaluate the susceptibility of HIV-1-infected cells to ADCC mediated by vaccine-elicited antibodies and several CD4i nnAbs (18, –, 33). This evidence concerns the gene ERVW-1 and infection.