The system organ classes with treatment-emergent adverse events most frequently reported were infections and infestations (combination group 33/46 (71.7%) and GH alone group 24/45 (53.3%)), nervous system disorders (21/46 (45.7%) and 17/45 (37.8%)) and musculoskeletal and connective tissue disorders (19/46 (41.3%) and 14/45 (31.1%)). The gene discussed is GH1; the disease is connective tissue disorder.