PDCD1 and non-small cell lung carcinoma: Nivolumab is a human IgG4 anti-PD1 monoclonal antibody which blocks the PD-1 receptor on activated T cells, which has been approved by the Food and Drug Administration for the treatment of patients with unresectable or metastatic melanoma unresponsive to other drugs, and relapsed non-small-cell lung cancer, recurrent renal cancer and lymphoma.