These abnormal α-syn species exhibit seeding activity to induce prion-like conversion, detergent-insolubility and protease-resistance of endogenous α-syn [38], being similar in these respects to the infectious forms of prion protein (PrPSc) causing Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy [45]. Here, PRNP is linked to Creutzfeldt Jacob disease.