For example, UCA1 could function as an endogenous sponge for miR-216b to regulate the expression of fibroblast growth factor receptor 1 (FGFR1) and the extracellular related kinase (ERK) signaling pathway in hepatocellular carcinoma [16], for miR-204-5p to upregulate CAMP responsive element binding protein 1 (CREB1) gene expression in colorectal cancer [18] and for miR-122 to promote glioma cell proliferation and invasion [51]. Here, CREB1 is linked to glioma.