Grouping patients with SSc according to the disease subset, we found that CD68+ cell count was significantly higher in clinically uninvolved skin from patients with SSc with a diffuse phenotype (14.8 ± 5.8) compared to patients with SSc with limited disease (8.3 ± 4.7) (p = 0.05), whereas there was no difference in macrophage infiltrate when comparing involved skin samples from patients with dSSc (27.2 ± 7.8) to skin samples from patients with lSSc (22.3 ± 11.7) (p = 0.78). The gene discussed is CD68; the disease is systemic sclerosis.