It is known that, even if these features might be occasionally presents in PFAPA subjects [12], the presence of abdominal pain and diarrhea, are much more associated with the probability to carry relevant mutations in MVK, TNFRSF1A and MEFV genes associated with mevalonate kinase deficiency, TRAPS and familial Mediterranean fever, respectively [14]. This evidence concerns the gene TNFRSF1A and familial Mediterranean fever.