Therefore, the aims of the present study were to assess the genotypic and allelic distribution of Bsm-I (rs1544410), Apa-I (rs7975232) and Taq-I (rs731236) polymorphisms of the VDR gene and to determine whether these gene variants are associated with 25-hydroxyvitamin D [25(OH)D] levels and with metabolic abnormalities, including MetS, in women with PCOS in comparison to non-hirsute, ovulatory control women. The gene discussed is VDR; the disease is metabolic syndrome.