It has been reported that PD-L1 expression is detected in 23.9% of ccRCC patients [10] and in 10.9% of non-ccRCC patients (5.6% in CRCC, 10% in PRCC, 30% in Xp11.2 translocation RCC, and 20% in collecting duct carcinoma) [4]; PD-L1 expression in RCC with sarcomatoid differentiation is extremely high. This evidence concerns the gene CD274 and renal cell carcinoma.