The use of dipeptidyl peptidase-4 (DPP-4) inhibitors to reduce daily glucose fluctuations has been associated with a reduction in oxidative stress and inflammation [24]: within a 3-month period, reduction in glycaemic variability caused a commensurate and proportionate reduction in carotid IMT [25], suggesting that glycaemic variability could be a potentially reversible early therapeutic target to partially address the increased CVD risk in those with T2DM. The gene discussed is DPP4; the disease is type 2 diabetes mellitus.