Immune repertoire profiling, i.e., the study of TR and BcR repertoires, is a prerequisite for diagnosis, prognostication and monitoring of hematological disorders (e.g., various lymphoid malignancies [1, 2]) and it commonly includes the quantification of 1) the diversity and expression of TR or BcR clonotypes, i.e., the distinct clones of T or B receptor cells in a biological sample, and 2) the V, D, J gene usage, i.e., the frequency at which the various germline V, D, J genes have been rearranged to generate the TR or BcR clonotypes in the sample. The gene discussed is BCR; the disease is hematologic disorder.