Amongst the top most significantly enriched gene sets bound by FOXA1/DIV are genes up-regulated in xenografts resistant to endocrine therapy (55), differentially upregulated in luminal as compared to basal or mesenchymal breast cancer cell lines (56), down regulated in breast cancer cells depleted of ESR1 (57) and other gene sets associated with response to nuclear receptor signaling and oncogenic pathways. The gene discussed is ESR1; the disease is breast cancer.